G-quadruplex ligands in cancer therapy: Progress, challenges, and clinical perspectives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F24%3A00584422" target="_blank" >RIV/68081707:_____/24:00584422 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0024320524000705?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0024320524000705?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.lfs.2024.122481" target="_blank" >10.1016/j.lfs.2024.122481</a>
Alternative languages
Result language
angličtina
Original language name
G-quadruplex ligands in cancer therapy: Progress, challenges, and clinical perspectives
Original language description
Guanine-rich sequences can form G-quadruplexes (G4) in living cells, making these structures promising anticancer targets. Compounds able to recognize these structures have been investigated as potential anticancer drugs, however, no G4 binder has yet been approved in the clinic. Here, we describe G4 ligands structure-activity relationships, in vivo effects as well as clinical trials. Addressing G4 ligand characteristics, targeting challenges, and structure-activity relationships, this review provides insights into the development of potent and selective G4-targeting molecules for therapeutic applications.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Life Sciences
ISSN
0024-3205
e-ISSN
1879-0631
Volume of the periodical
340
Issue of the periodical within the volume
MAR 1 2024
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
122481
UT code for WoS article
001178480100001
EID of the result in the Scopus database
2-s2.0-85184032688