Down-regulation of vimentin by triorganotin isothiocyanates—nuclear retinoid X receptor agonists: A proteomic approach

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081715%3A_____%2F20%3A00510284" target="_blank" >RIV/68081715:_____/20:00510284 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14160/20:00118220 RIV/62157124:16370/20:43878591

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0378427419303236?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0378427419303236?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.toxlet.2019.10.004" target="_blank" >10.1016/j.toxlet.2019.10.004</a>

Result language

angličtina

Original language name

Down-regulation of vimentin by triorganotin isothiocyanates—nuclear retinoid X receptor agonists: A proteomic approach

Original language description

An attempt has been made to delineate the role of natural and synthetic retinoid receptor ligands on vimentin expression in the human triple-negative breast cancer cells. The effects of currently synthesized triorganotinnderivatives of the general formula R3SnX (R is butyl or phenyl, X is isothiocyanate), which are considered RXR igands, were investigated in the human MDA-MB-231 breast cancer cell line. Studies were evaluated in thenpresence and absence of all-trans retinoic acid (ATRA), a natural RAR ligand. Vimentin represents the major protein associated with epithelial-mesenchymal transition (EMT), an essential process when the primary tumourntransforms into a malignant one. mRNA and proteomic data obtained in this study, based on the PDQuest software protein evaluation and further quantification of proteins by iTRAQ analysis, suggest that vimentin wasnsignificantly reduced in the combination of RAR ligand and RXR ligand treatment. Both tested triorganotin compounds showed similarly reduced expression of vimentin, but tributyltin isothiocyanate (TBT-ITC) proved tonbe more effective than triphenyltin isothiocyanate (TPT-ITC). Furthermore, the effect of natural (9cRA) and synthetic RXR ligands, both chloride and isothiocyanate derivatives, on vimentin expression was compared.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10406 - Analytical chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology Letters

ISSN

0378-4274

e-ISSN

—

Volume of the periodical

318

Issue of the periodical within the volume

JAN

Country of publishing house

IE - IRELAND

Number of pages

8

Pages from-to

22-29

UT code for WoS article

000496792900003

EID of the result in the Scopus database

2-s2.0-85074143518