Proteomics of mouse heart ventricles reveals mitochondria and metabolism as major targets of a post-infarction short-acting glp1ra-therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081715%3A_____%2F21%3A00545023" target="_blank" >RIV/68081715:_____/21:00545023 - isvavai.cz</a>
Result on the web
<a href="http://hdl.handle.net/11104/0321801" target="_blank" >http://hdl.handle.net/11104/0321801</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms22168711" target="_blank" >10.3390/ijms22168711</a>

Result language
angličtina
Original language name
Proteomics of mouse heart ventricles reveals mitochondria and metabolism as major targets of a post-infarction short-acting glp1ra-therapy
Original language description
The global proteomics was employed to interrogate the target proteins, organelles and biological processes affected by short-acting GLP1Ra administered after permanent coronary artery ligation (PCAL).This approach showed a central role for mitochondria and mitochondria-associated metabolic pathways, such as fatty acid oxidation, in the beneficial effects of short-acting GLP1Ra on postinfarttion remodeling. The overexpression of proteins identified by protein-protein interaction networks, such as Atp2a2, may be important to the mechanism of action of GLP1Ra.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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