Fragment-based approach to study fungicide-biomimetic membrane interactions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081715%3A_____%2F24%3A00587956" target="_blank" >RIV/68081715:_____/24:00587956 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2024/sm/d4sm00648h" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2024/sm/d4sm00648h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d4sm00648h" target="_blank" >10.1039/d4sm00648h</a>
Alternative languages
Result language
angličtina
Original language name
Fragment-based approach to study fungicide-biomimetic membrane interactions
Original language description
In this study, the molecular interactions of the allylamine-type fungicide butenafine and a set of substructures (fragments) with liposomes mimicking biological membranes were studied to gain a better understanding of the structural factors governing membrane affinity and perturbation. Specifically, drug/fragment-membrane interactions were investigated using an interdisciplinary approach involving micro differential scanning calorimetry, open-tubular capillary electrochromatography, nanoplasmonic sensing, and quartz crystal microbalance. By incubating the drug and the fragment compounds with liposomes with varying lipid composition or by externally adding the compounds to preformed liposomes, a detailed mechanistic picture on the underlying drug/fragment-membrane interactions was obtained. The nature and the degree of ionisation of polar head groups of the lipids had a major influence on the nature of drug-membrane interactions, and so had the presence and relative concentration of cholesterol within the membranes. The in-depth understanding of drug/fragment-membranes interactions established by the presented interdisciplinary fragment-based approach may be useful in guiding the design and early-stage evaluation of prospective antifungal drug candidates, and the discovery of agents with improved membrane penetrating characteristics in general.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Soft Matter
ISSN
1744-683X
e-ISSN
1744-6848
Volume of the periodical
20
Issue of the periodical within the volume
30
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
5954-5968
UT code for WoS article
001271066400001
EID of the result in the Scopus database
2-s2.0-85198992286