The precision of DCE-MRI using the tissue homogeneity model with continuous formulation of the perfusion parameters

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F14%3A00431811" target="_blank" >RIV/68081731:_____/14:00431811 - isvavai.cz</a>
Alternative codes found
RIV/67985556:_____/14:00431811 RIV/00216305:26220/14:PU107765
Result on the web
<a href="http://dx.doi.org/10.1016/j.mri.2014.02.003" target="_blank" >http://dx.doi.org/10.1016/j.mri.2014.02.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mri.2014.02.003" target="_blank" >10.1016/j.mri.2014.02.003</a>

Result language
angličtina
Original language name
The precision of DCE-MRI using the tissue homogeneity model with continuous formulation of the perfusion parameters
Original language description
The present trend in dynamic contrast-enhanced MRI is to increase the number of estimated perfusion parameters using complex pharmacokinetic models. However, less attention is given to the precision analysis of the parameter estimates. In this paper, thedistributed capillary adiabatic tissue homogeneity pharmacokinetic model is extended by the bolus arrival time formulated as a free continuous parameter. With the continuous formulation of all perfusion parameters, it is possible to use standard gradient-based optimization algorithms in the approximation of the-tissue concentration time sequences. This new six-parameter model is investigated by comparing Monte-Carlo simulations with theoretically derived covariance matrices. The covariance-matrix approach is extended from the usual analysis of the primary perfusion parameters of the pharmacokinetic model to the analysis of the perfusion parameters derived from the primary ones. The results indicate that the precision of the estimated p
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FS - Medical facilities, apparatus and equipment
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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