The functional organization of human epileptic hippocampus
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F16%3A00466972" target="_blank" >RIV/68081731:_____/16:00466972 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/16:00065637 RIV/00216305:26220/16:PU118843
Result on the web
<a href="http://dx.doi.org/10.1152/jn.00089.2016" target="_blank" >http://dx.doi.org/10.1152/jn.00089.2016</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1152/jn.00089.2016" target="_blank" >10.1152/jn.00089.2016</a>
Alternative languages
Result language
angličtina
Original language name
The functional organization of human epileptic hippocampus
Original language description
The function and connectivity of human brain is disrupted in epilepsy. We previously reported that the region of epileptic brain generating focal seizures, i.e., the seizure onset zone (SOZ), is functionally isolated from surrounding brain regions in focal neocortical epilepsy. The modulatory effect of behavioral state on the spatial and spectral scales over which the reduced functional connectivity occurs, however, is unclear. Here we usensimultaneous sleep staging from scalp EEG with intracranial EEG recordings from medial temporal lobe to investigate how behavioral state modulates the spatial and spectral scales of local field potential synchronynin focal epileptic hippocampus. The local field spectral power and linear correlation between adjacent electrodes provide measures of neuronal population synchrony at different spatial scales, respectively. Our results show increased connectivity inside the SOZ and lownconnectivity between electrodes in SOZ and outside the SOZ. During slow-wave sleep, we observed decreased connectivity for ripple and fast ripple frequency bands within the SOZ at the 10 mm spatial scale, whilenthe local synchrony remained high at the 1 mm spatial scale. Further study of these phenomena may prove useful for SOZ localization and help understand seizure generation, and the functional deficits seen in epileptic eloquent cortex.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neurophysiology
ISSN
0022-3077
e-ISSN
—
Volume of the periodical
115
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
3140-3145
UT code for WoS article
—
EID of the result in the Scopus database
2-s2.0-84984853893