Improved assessment of arterial stiffness using corrected cardio-ankle vascular index (CAVI0) in overweight adolescents with white-coat and essential hypertension

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F17%3A00482732" target="_blank" >RIV/68081731:_____/17:00482732 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26220/17:PU125276

Result on the web

<a href="http://dx.doi.org/10.1080/00365513.2017.1397286" target="_blank" >http://dx.doi.org/10.1080/00365513.2017.1397286</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00365513.2017.1397286" target="_blank" >10.1080/00365513.2017.1397286</a>

Result language

angličtina

Original language name

Improved assessment of arterial stiffness using corrected cardio-ankle vascular index (CAVI0) in overweight adolescents with white-coat and essential hypertension

Original language description

Arterial stiffness is a marker of vascular damage. Although adiposity increases cardiovascular risk, the relationship between paediatric overweight and arterial stiffness is unclear. The study aimed to evaluate the simultaneous effect of hypertension and overweight on arterial stiffness using cardio-ankle vascular index (CAVI) and related novel, theoretically blood pressure (BP)-independent, index CAVI(0). CAVI and CAVI(0) were measured in 140 adolescent boys (16.0 +/- 1.9 years) divided into age-matched groups: normal-weight normotensives, overweight normotensives, overweight white-coat hypertensives, and overweight essential hypertensives. Overweight normotensives had significantly lower CAVI and CAVI(0) compared to normal-weight normotensives (4.81 +/- 0.64 vs. 5.33 +/- 0.66, p<.01, 7.10 +/- 0.99 vs. 7.81 +/- 1.00, p<.01, respectively). CAVI and CAVI(0) in overweight essential hypertensives showed no significant difference compared to normal-weight normotensives and were significantly higher compared to overweight normotensives (5.32 +/- 0.77 vs. 4.81 +/- 0.64, p<.01, 7.77 +/- 1.19 vs. 7.10 +/- 0.99, p<.01, respectively). CAVI, but not CAVI0, was associated positively with diastolic pressure (0.022 mm Hg-1, p=.002) and negatively with pulse pressure (-0.022 mm Hg-1, p=.001), and it was significantly higher in overweight white-coat hypertensives compared to overweight normotensives (5.20 +/- 0.63 vs. 4.81 +/- 0.64, p<.05). The lowering effect of overweight on arterial stiffness indexed by CAVI and CAVI(0) in hypertensive adolescents seems to counterbalance the early arteriosclerotic effect of essential hypertension. The increase in CAVI, but not CAVI(0), in overweight white-coat hypertensives could be attributable to residual BP dependence of CAVI, which is not present in CAVI(0). Under certain conditions, CAVI(0) may offer a clinically relevant improved assessment of arterial stiffness superior to CAVI.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20601 - Medical engineering

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scandinavian Journal of Clinical and Laboratory Investigation

ISSN

0036-5513

e-ISSN

—

Volume of the periodical

77

Issue of the periodical within the volume

8

Country of publishing house

NO - NORWAY

Number of pages

8

Pages from-to

665-672

UT code for WoS article

000416756100017

EID of the result in the Scopus database

2-s2.0-85033433032