Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F18%3A00494595" target="_blank" >RIV/68081731:_____/18:00494595 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1177/0271678X17714656" target="_blank" >http://dx.doi.org/10.1177/0271678X17714656</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/0271678X17714656" target="_blank" >10.1177/0271678X17714656</a>

Result language
angličtina
Original language name
Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma
Original language description
Neo-angiogenesis represents an important factor for the delivery of oxygen and nutrients to a growing tumour, and is considered to be one of the main pathodiagnostic features of glioblastomas (GBM). Anti-angiogenic therapy by vascular endothelial growth factor (VEGF) blocking agents has been shown to lead to morphological vascular normalisation resulting in a reduction of contrast enhancement as seen by magnetic resonance imaging (MRI). Yet the functional consequences of this normalisation and its potential for improved delivery of cytotoxic agents to the tumour are not known. The presented study aimed at determining the early physiologic changes following bevacizumab treatment. A time series of perfusion MRI and hypoxia positron emission tomography (PET) scans were acquired during the first week of treatment, in two human GBM xenograft models treated with either high or low doses of bevacizumab. We show that vascular morphology was normalised over the time period investigated, but vascular function was not improved, resulting in poor tumoural blood flow and increased hypoxia.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
<a href="/en/project/GA16-13830S" target="_blank" >GA16-13830S: Magnetic resonance perfusion imaging using compressed sensing</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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