Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F21%3A00536954" target="_blank" >RIV/68081731:_____/21:00536954 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/nbm.4393" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/nbm.4393</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/nbm.4393" target="_blank" >10.1002/nbm.4393</a>

Result language
angličtina
Original language name
Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations
Original language description
Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower peaks of metabolites and often complicate their quantification but they also may have potential importance as biomarkers in specific diseases. Thus, separation of broad MM signals from low molecular weight metabolites enables accurate determination of metabolite concentrations and is of primary interest in many studies. Other studies attempt to understand the origin of the MM spectrum, to decompose it into individual spectral regions or peaks and to use the components of the MM spectrum as markers of various physiological or pathological conditions in biomedical research or clinical practice. The aim of this consensus paper is to provide an overview and some recommendations on how to handle the MM signals in different types of studies together with a list of open issues in the field, which are all summarized at the end of the paper.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20601 - Medical engineering

Project
<a href="/en/project/EF16_013%2F0001775" target="_blank" >EF16_013/0001775: Modernization and support of research activities of the national infrastructure for biological and medical imaging Czech-BioImaging</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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