Polarization-resolved second-harmonic generation imaging through a multimode fiber
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F21%3A00544708" target="_blank" >RIV/68081731:_____/21:00544708 - isvavai.cz</a>
Result on the web
<a href="https://www.osapublishing.org/optica/fulltext.cfm?uri=optica-8-8-1065&id=453930" target="_blank" >https://www.osapublishing.org/optica/fulltext.cfm?uri=optica-8-8-1065&id=453930</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1364/OPTICA.430295" target="_blank" >10.1364/OPTICA.430295</a>
Alternative languages
Result language
angličtina
Original language name
Polarization-resolved second-harmonic generation imaging through a multimode fiber
Original language description
Multimode fiber-based endoscopes have recently emerged as a tool for minimally invasive endoscopy in tissue, at depths well beyond the reach of multiphoton imaging. Here, we demonstrate label-free second-harmonic generation (SHG) microscopy through such a fiber endoscope. We simultaneously fully control the excitation polarization state and the spatial distribution of the light at the fiber tip, and we use this to implement polarization-resolved SHG imaging, which allows imaging and identification of structural proteins such as collagen and myosin.We image mouse tail tendon and heart tissue, employing the endoscope at depths up to 1 mm, demonstrating that we can differentiate these structural proteins. This method has the potential for enabling instant and in situ diagnosis of tumors and fibrotic conditions insensitive tissue with minimal damage.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10306 - Optics (including laser optics and quantum optics)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Optica
ISSN
2334-2536
e-ISSN
2334-2536
Volume of the periodical
8
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1065-1074
UT code for WoS article
000687747700005
EID of the result in the Scopus database
2-s2.0-85111981587