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Polarization-resolved second-harmonic generation imaging through a multimode fiber

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F21%3A00544708" target="_blank" >RIV/68081731:_____/21:00544708 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.osapublishing.org/optica/fulltext.cfm?uri=optica-8-8-1065&id=453930" target="_blank" >https://www.osapublishing.org/optica/fulltext.cfm?uri=optica-8-8-1065&id=453930</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1364/OPTICA.430295" target="_blank" >10.1364/OPTICA.430295</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Polarization-resolved second-harmonic generation imaging through a multimode fiber

  • Original language description

    Multimode fiber-based endoscopes have recently emerged as a tool for minimally invasive endoscopy in tissue, at depths well beyond the reach of multiphoton imaging. Here, we demonstrate label-free second-harmonic generation (SHG) microscopy through such a fiber endoscope. We simultaneously fully control the excitation polarization state and the spatial distribution of the light at the fiber tip, and we use this to implement polarization-resolved SHG imaging, which allows imaging and identification of structural proteins such as collagen and myosin.We image mouse tail tendon and heart tissue, employing the endoscope at depths up to 1 mm, demonstrating that we can differentiate these structural proteins. This method has the potential for enabling instant and in situ diagnosis of tumors and fibrotic conditions insensitive tissue with minimal damage.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10306 - Optics (including laser optics and quantum optics)

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Optica

  • ISSN

    2334-2536

  • e-ISSN

    2334-2536

  • Volume of the periodical

    8

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    1065-1074

  • UT code for WoS article

    000687747700005

  • EID of the result in the Scopus database

    2-s2.0-85111981587