Comparing Ventricular Synchrony in Left Bundle Branch and Left Ventricular Septal Pacing in Pacemaker Patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F21%3A00559959" target="_blank" >RIV/68081731:_____/21:00559959 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/21:43921227 RIV/00216305:26220/21:PU141455 RIV/00064173:_____/21:N0000079

Result on the web

<a href="https://www.mdpi.com/2077-0383/10/4/822" target="_blank" >https://www.mdpi.com/2077-0383/10/4/822</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/jcm10040822" target="_blank" >10.3390/jcm10040822</a>

Result language

angličtina

Original language name

Comparing Ventricular Synchrony in Left Bundle Branch and Left Ventricular Septal Pacing in Pacemaker Patients

Original language description

Background: Left bundle branch area pacing (LBBAP) has recently been introduced as a novel physiological pacing strategy. Within LBBAP, distinction is made between left bundle branch pacing (LBBP) and left ventricular septal pacing (LVSP, no left bundle capture). Objective: To investigate acute electrophysiological effects of LBBP and LVSP as compared to intrinsic ventricular conduction. Methods: Fifty patients with normal cardiac function and pacemaker indication for bradycardia underwent LBBAP. Electrocardiography (ECG) characteristics were evaluated during pacing at various depths within the septum: starting at the right ventricular (RV) side of the septum: the last position with QS morphology, the first position with r' morphology, LVSP and-in patients where left bundle branch (LBB) capture was achieved-LBBP. From the ECG's QRS duration and QRS morphology in lead V1, the stimulus- left ventricular activation time left ventricular activation time (LVAT) interval were measured. After conversion of the ECG into vectorcardiogram (VCG) (Kors conversion matrix), QRS area and QRS vector in transverse plane (Azimuth) were determined. Results: QRS area significantly decreased from 82 +/- 29 mu Vs during RV septal pacing (RVSP) to 46 +/- 12 mu Vs during LVSP. In the subgroup where LBB capture was achieved (n = 31), QRS area significantly decreased from 46 +/- 17 mu Vs during LVSP to 38 +/- 15 mu Vs during LBBP, while LVAT was not significantly different between LVSP and LBBP. In patients with normal ventricular activation and narrow QRS, QRS area during LBBP was not significantly different from that during intrinsic activation (37 +/- 16 vs. 35 +/- 19 mu Vs, respectively). The Azimuth significantly changed from RVSP (-46 +/- 33 degrees) to LVSP (19 +/- 16 degrees) and LBBP (-22 +/- 14 degrees). The Azimuth during both LVSP and LBBP were not significantly different from normal ventricular activation. QRS area and LVAT correlated moderately (Spearman's R = 0.58). Conclusions: ECG and VCG indices demonstrate that both LVSP and LBBP improve ventricular dyssynchrony considerably as compared to RVSP, to values close to normal ventricular activation. LBBP seems to result in a small, but significant, improvement in ventricular synchrony as compared to LVSP.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical Medicine

ISSN

2077-0383

e-ISSN

2077-0383

Volume of the periodical

10

Issue of the periodical within the volume

4

Country of publishing house

CH - SWITZERLAND

Number of pages

12

Pages from-to

822

UT code for WoS article

000624037000001

EID of the result in the Scopus database

2-s2.0-85114081648