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Are there differences in EEG between epileptic patients with vagal nerve stimulation (VNS) and healthy controls?

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F22%3A00559442" target="_blank" >RIV/68081731:_____/22:00559442 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/22:00129747

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/10.1111/ene.15466" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/ene.15466</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Are there differences in EEG between epileptic patients with vagal nerve stimulation (VNS) and healthy controls?

  • Original language description

    Background and aims: The presented work is based on the results of our published work, in which we focused on the VNS efficacy prediction in patients with drug-resistant epilepsy. We found that there are differences in power spectra between VNS responders and non-responders. We asked two more questions. Are there differences between the epileptic patients with VNS and healthy controls? Do the EEG power spectra in healthy controls resemble more responders or non-responders to VNS therapy? Methods: We identified retrospectively EEG recording in epileptic patients with VNS and in healthy controls. The epileptic patients were classified based on the VNS efficacy as responder and non-responders EEG was segmented into several time-intervals (resting-state, eyes-opening 1, resting state, photic stimulation, hyperventilation, eyes opening 2, resting state 3 and resting state) and frequency bands. Subsequently, we established relative EEG power spectra in pre-defined frequency bands and time-intervals. Results: We identified EEG in 56 healthy controls and in 60 epileptic patients with VNS (35 responders, 25 non-responders). When compared healthy controls and epileptic patients, we identified EEG power spectra differences in theta (eyes-opening 1, 2), alpha (eyes-opening 1,2) and beta frequency range (eyes-opening 1). When compared responders to VNS therapy and healthy controls, we found more significant differences than in non-responders. Conclusion: There are differences in EEG power spectra between epileptic patients treated with VNS and healthy controls. These differences are present in more frequency bands and time-intervals. However, non-responders resemble healthy population more than responders. The question is whether we can employ these results for pre-implantation VNS prediction.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    30103 - Neurosciences (including psychophysiology)

Result continuities

  • Project

    <a href="/en/project/NV19-04-00343" target="_blank" >NV19-04-00343: Prediction of Stimulation Efficacy in Epilepsy (PRESEnCE)</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů