Laterality in functional and metabolic state of the bulbectomised rat brain detected by ASL and 1H MRS: A pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F23%3A00565353" target="_blank" >RIV/68081731:_____/23:00565353 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00130038

Result on the web

<a href="https://www.tandfonline.com/doi/full/10.1080/15622975.2022.2124450" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/15622975.2022.2124450</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/15622975.2022.2124450" target="_blank" >10.1080/15622975.2022.2124450</a>

Result language

angličtina

Original language name

Laterality in functional and metabolic state of the bulbectomised rat brain detected by ASL and 1H MRS: A pilot study

Original language description

Objectives Pilot study validating the animal model of depression the bilateral olfactory bulbectomy in rats by two nuclear magnetic resonance methods, indirectly detecting the metabolic state of the brain. Furthermore, the study focussed on potential differences in brain laterality. Methods Arterial spin labelling assessed cerebral brain flow in prefrontal, sensorimotor, and piriform cortices, nucleus accumbens, hippocampus, thalamus, circle of Willis, and whole brain. Proton magnetic resonance spectroscopy provided information about relative metabolite concentrations in the cortex and hippocampus. Results Arterial spin labelling found no differences in cerebral perfusion in the group comparison but revealed lateralisation in the thalamus of the control group and the sensorimotor cortex of the bulbectomized rats. Lower Cho/tCr and Cho/NAA levels were found in the right hippocampus in bulbectomized rats. The differences in lateralisation were shown in the hippocampus: mI/tCr in the control group, Cho/NAA, NAA/tCr, Tau/tCr in the model group, and in the cortex: NAA/tCr, mI/tCr in the control group. Conclusion Olfactory bulbectomy affects the neuronal and biochemical profile of the rat brain laterally and, as a model of depression, was validated by two nuclear magnetic resonance methods.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

World Journal of Biological Psychiatry

ISSN

1562-2975

e-ISSN

1814-1412

Volume of the periodical

24

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

414-428

UT code for WoS article

000861426500001

EID of the result in the Scopus database

2-s2.0-85141045649