Stress, epileptiform symptoms in schizophrenia and neural information transmission

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F25%3A00619873" target="_blank" >RIV/68081731:_____/25:00619873 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/25:00143950 RIV/00216208:11110/25:10498471

Result on the web

<a href="https://www.degruyterbrill.com/document/doi/10.1515/tnsci-2025-0372/html" target="_blank" >https://www.degruyterbrill.com/document/doi/10.1515/tnsci-2025-0372/html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/tnsci-2025-0372" target="_blank" >10.1515/tnsci-2025-0372</a>

Result language

angličtina

Original language name

Stress, epileptiform symptoms in schizophrenia and neural information transmission

Original language description

Background Several findings indicate that stress may influence epileptiform discharges manifesting in temporal-limbic areas, which may become a potential trigger of psychosis that may manifest without neurologically diagnosed epilepsy. Some findings suggest that measures assessing levels of inter-hemispheric information connection may reveal the spread of subclinical epileptiform neural activity associated with psychotic and seizure-like symptoms. Recent research also suggests that electrodermal activity (EDA), which is related to limbic activations, may allow indirect measurement of interhemispheric information transmission. These findings about the interhemispheric spread of information suggest a hypothesis that heightened spread of information between the brain hemispheres might indirectly indicate epileptiform discharges spreading between hemispheres. Methods We have analyzed and measured EDA and also cognitive and affective epileptic-like symptoms (CPSI, complex partial seizure-like symptoms), symptoms of chronic stress (Trauma Symptoms Checklist-40, TSC-40), and psychotic symptoms in 31 schizophrenia patients and compared these data with 31 healthy controls. Results The results indicate that in schizophrenia patients, the values of pointwise transinformation (PTI) calculated from right and left EDA time series are related to CPSI symptoms (Spearman correlation between CPSI and PTI is R = 0.48, p < 0.01) and symptoms of chronic stress (Spearman correlation between TSC-40 and PTI is R = 0.37, p < 0.05), both during mild stress conditions caused by conflicting (incongruent) Stroop task. Conclusion The analysis indicates potentially diagnostically useful results suggesting that heightened PTI values may reflect autonomic activations that hypothetically might be linked to higher interhemispheric transmission related to spreading of epileptiform discharges between hemispheres.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Translational Neuroscience

ISSN

2081-3856

e-ISSN

2081-6936

Volume of the periodical

16

Issue of the periodical within the volume

1

Country of publishing house

PL - POLAND

Number of pages

7

Pages from-to

20250372

UT code for WoS article

001487856700001

EID of the result in the Scopus database

2-s2.0-105005619618