The state of vigilance and not antiseizure medication dosage drive variability in interictal epilepsy biomarkers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F25%3A00638567" target="_blank" >RIV/68081731:_____/25:00638567 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/25:00082392 RIV/00216224:14110/25:00141884 RIV/00216305:26220/26:0199134
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1388245725006777" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1388245725006777</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clinph.2025.2110825" target="_blank" >10.1016/j.clinph.2025.2110825</a>
Alternative languages
Result language
angličtina
Original language name
The state of vigilance and not antiseizure medication dosage drive variability in interictal epilepsy biomarkers
Original language description
Objective: During presurgical intracranial electroencephalography (iEEG) investigation, anti-seizure medication (ASM) is typically tapered to record seizures. Interictal biomarkers are critical for epileptogenic zone (EZ) localization. This study examines how ASM tapering and other confounding factors influence the rates and localization accuracy of interictal iEEG biomarkers. Methods: iEEG data from 19 patients were analyzed during two 24 h sections separated by at least seven days during > 10-day iEEG monitoring. ASM dosage, vigilance state, time of day, seizure proximity, and duration of monitoring were evaluated for their impact on interictal biomarker rates, spatial distribution and localization of the EZ. Results: Biomarker rates, spatial distributions, and EZ localization did not significantly differ between the two 24hour sections. The state of vigilance emerged as the most significant contributor explaining 22.7 % of the variability. Seizure proximity, time of day and ASM dosage contributed minimally, each accounting for <= 3.7 % of the variability. Conclusions: The state of vigilance is the most significant determinant of interictal biomarker variability, and exceeds the impact of all other confounding factors regarding biomarker rates, distribution, and EZ localization. Significance: These findings highlight the importance of vigilance state over ASM tapering, supporting the potential use of interictal biomarkers for EZ localization, regardless of ASM adjustments.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
<a href="/en/project/LX22NPO5107" target="_blank" >LX22NPO5107: National institute for Neurological Research</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Neurophysiology
ISSN
1388-2457
e-ISSN
1872-8952
Volume of the periodical
177
Issue of the periodical within the volume
September
Country of publishing house
IE - IRELAND
Number of pages
10
Pages from-to
2110825
UT code for WoS article
001555554600002
EID of the result in the Scopus database
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