Multiscale analysis of mechanical and structural properties of agarose-silk fibroin hydrogels

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F25%3A00640852" target="_blank" >RIV/68081731:_____/25:00640852 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21220/25:00385679 RIV/00216305:26310/26:0199743

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0141813025086908" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0141813025086908</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijbiomac.2025.148133" target="_blank" >10.1016/j.ijbiomac.2025.148133</a>

Result language

angličtina

Original language name

Multiscale analysis of mechanical and structural properties of agarose-silk fibroin hydrogels

Original language description

This study provides a comprehensive characterization of the agarose-silk fibroin hydrogels, using atomic force microscopy and scanning transmission electron microscopy to analyse their structure and assess the effect of composition on mechanical properties via nanoindentation and rheological analysis. These measurements enabled determination of mechanical properties, including the elastic and viscoelastic moduli at both the microand macroscale. The hydrogels exhibited a wide range of moduli depending on different degrees of network crosslinking, influenced by varying concentrations of agarose (1 or 2 wt%) and the percentage of fibroin fibres (0-4.5 wt%) as an interpenetrating component. The viscoelastic modulus (G') and the elastic modulus determined using a relaxation model (E), were 5-57 kPa and 1.2-110 kPa, respectively. The adhesion energy of these hydrogels was determined from nanoindentation curves and analysed using the JKR model, with values ranging from 0.031 to 0.066 J m-2. These results provide insight into how the hydrogels' microstructure influences their mechanical and transport properties. Incorporating fibroin into these gels modifies biological and biochemical characteristics of the gels, suggesting that such composite hydrogels could be further explored for potential applications in controlled release systems, extracellular matrix models, or tissue engineering scaffolds.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10403 - Physical chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Biological Macromolecules

ISSN

0141-8130

e-ISSN

1879-0003

Volume of the periodical

330

Issue of the periodical within the volume

3

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

13

Pages from-to

148133

UT code for WoS article

001596413500014

EID of the result in the Scopus database

2-s2.0-105018055217