Relationship between remnant hippocampus and amygdala and memory outcomes after stereotactic surgery for mesial temporal lobe epilepsy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081740%3A_____%2F15%3A00450859" target="_blank" >RIV/68081740:_____/15:00450859 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/15:10316084 RIV/00216208:11120/15:43910500

Result on the web

<a href="http://dx.doi.org/10.2147/NDT.S95497" target="_blank" >http://dx.doi.org/10.2147/NDT.S95497</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/NDT.S95497" target="_blank" >10.2147/NDT.S95497</a>

Result language

angličtina

Original language name

Relationship between remnant hippocampus and amygdala and memory outcomes after stereotactic surgery for mesial temporal lobe epilepsy

Original language description

Mesial temporal structures play an important role in human memory. In mesial temporal lobe epilepsy (MTLE), seizure activity is generated from the same structures. Surgery is the definitive treatment for medically intractable MTLE. In addition to standard temporal lobe microsurgical resection, stereotactic radiofrequency amygdalohippocampectomy (SAHE) is used as an alternative MTLE treatment. While memory impairments after standard epilepsy surgery are well known, it has been shown that memory decline is not a feature of SAHE. The aim of the present study was to correlate the volume of the remnant hippocampus and amygdala in patients treated by SAHE with changes in memory parameters. Thirty-seven MTLE patients treated by SAHE (ten right, 27 left) were included. Patients underwent MRI examinations including hippocampal and amygdalar volumetry and neuropsychological evaluation preoperatively and 1 year after surgery. Larger left-sided hippocampal reductions were associated with lower verbal memory performance (ρ=-0.46 P=0.02). On the contrary, improvement of global memory quotient (MQ) was positively correlated with larger right-sided hippocampal reduction (ρ=0.66 P=0.04). Similarly, positive correlations between the extent of right amygdalar reduction and verbal MQ (ρ=0.74 P=0.02) and global MQ change (ρ=0.69 P=0.03) were found. Thus, larger right hippocampal and amygdalar reduction was associated with higher global and verbal MQ change after SAHE. Larger left-sided hippocampal reductions were associated with lower verbal memory performance. This finding is in accordance with the material-specific model of human memory, which states that the dominant hemisphere is specialized for the learning and recall of verbal information. We hypothesize that larger right-sided ablations enable the left temporal lobe to support memory more effectively, perhaps as a consequence of epileptiform discharges spreading from remnants of right mesiotemporal structures to the left.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

50101 - Psychology (including human - machine relations)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuropsychiatric Disease and Treatment

ISSN

1178-2021

e-ISSN

—

Volume of the periodical

2015

Issue of the periodical within the volume

11

Country of publishing house

NZ - NEW ZEALAND

Number of pages

6

Pages from-to

2927-2932

UT code for WoS article

000365303700001

EID of the result in the Scopus database

2-s2.0-84947811077