A revised timescale for human evolution based on ancient mitochondrial genomes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081758%3A_____%2F13%3A00485576" target="_blank" >RIV/68081758:_____/13:00485576 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.cub.2013.02.044" target="_blank" >http://dx.doi.org/10.1016/j.cub.2013.02.044</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cub.2013.02.044" target="_blank" >10.1016/j.cub.2013.02.044</a>

Result language
angličtina
Original language name
A revised timescale for human evolution based on ancient mitochondrial genomes
Original language description
Background: Recent analyses of de novo DNA mutations in modern humans have suggested a nuclear substitution rate that is approximately half that of previous estimates based on fossil calibration. This result has led to suggestions that major events in human evolution occurred far earlier than previously thought. Results: Here, we use mitochondrial genome sequences from ten securely dated ancient modern humans spanning 40,000 years as calibration points for the mitochondrial clock, thus yielding a direct estimate of the mitochondrial substitution rate. Our clock yields mitochondrial divergence times that are in agreement with earlier estimates based on calibration points derived from either fossils or archaeological material. In particular, our results imply a separation of non-Africans from the most closely related sub-Saharan African mitochondrial DNAs (haplogroup L3) that occurred less than 62-95 kya. Conclusions: Though single loci like mitochondrial DNA (mtDNA) can only provide biased estimates of population divergence times, they can provide valid upper bounds. Our results exclude most of the older dates for African and non-African population divergences recently suggested by de novo mutation rate estimates in the nuclear genome.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
60102 - Archaeology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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