Polymorphism in vkorc1 Gene of Natal Multimammate Mice, Mastomys natalensis in Tanzania
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F15%3A00449034" target="_blank" >RIV/68081766:_____/15:00449034 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/jhered/esv054" target="_blank" >http://dx.doi.org/10.1093/jhered/esv054</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/jhered/esv054" target="_blank" >10.1093/jhered/esv054</a>
Alternative languages
Result language
angličtina
Original language name
Polymorphism in vkorc1 Gene of Natal Multimammate Mice, Mastomys natalensis in Tanzania
Original language description
Resistance of rodents to anticoagulant rodenticides has emerged in several areas across the world. Single nucleotide mutations in the vkorc1 gene have been shown to elicit various levels of anticoagulant resistance, and these mutations are prevalent in several Rattus and Mus musculus populations. In sub-Saharan Africa, the Natal multimammate mouse, Mastomys natalensis, is one of the most damaging pests to crops, and anticoagulant poisons such as bromadiolone are frequently used to control these rodentsin agricultural fields. Here, we investigate if vkorc1 shows any polymorphism in natural populations of M. natalensis. We sequenced the third exon of vkorc1 of 162 M. natalensis captured from 14 different agricultural sites in Morogoro Region, Tanzania.In addition to 6 SNPs in the noncoding flanking region, we detected 3 nonsynonymous SNPs in this exon: 10 animals (6.2%) carried a Leu108Val variant, 2 animals (1.2%) an Ala140Thr variant, and 1 animal (0.6 %) an Arg100His variant, all 3
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Heredity
ISSN
0022-1503
e-ISSN
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Volume of the periodical
106
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
637-643
UT code for WoS article
000361764100006
EID of the result in the Scopus database
2-s2.0-84941729752