Evidence for an ancestral association of human coronavirus 229E with bats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F15%3A00454688" target="_blank" >RIV/68081766:_____/15:00454688 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1128/JVI.01755-15" target="_blank" >http://dx.doi.org/10.1128/JVI.01755-15</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/JVI.01755-15" target="_blank" >10.1128/JVI.01755-15</a>
Alternative languages
Result language
angličtina
Original language name
Evidence for an ancestral association of human coronavirus 229E with bats
Original language description
We previously showed that close relatives of human coronavirus 229E (HCoV-229E) exist in African bats. The small sample and limited genomic characterizations have prevented further analyses so far. Here, we tested 2,087 fecal specimens from 11 bat species sampled in Ghana for HCoV-229E-related viruses by reverse transcription-PCR (RT-PCR). Only hipposiderid bats tested positive. To compare the genetic diversity of bat viruses and HCoV-229E, we tested historical isolates and diagnostic specimens sampledglobally over 10 years. Bat viruses were 5- and 6-fold more diversified than HCoV-229E in the RNA-dependent RNA polymerase (RdRp) and spike genes. In phylogenetic analyses, HCoV-229E strains were monophyletic and not intermixed with animal viruses. Bat viruses formed three large clades in close and more distant sister relationships. A recently described 229E-related alpaca virus occupied an intermediate phylogenetic position between bat and human viruses. According to taxonomic criteria,
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Virology
ISSN
0022-538X
e-ISSN
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Volume of the periodical
89
Issue of the periodical within the volume
23
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
11858-11870
UT code for WoS article
000366896600011
EID of the result in the Scopus database
2-s2.0-84949527785