From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F16%3A00443676" target="_blank" >RIV/68081766:_____/16:00443676 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/brv.12183" target="_blank" >http://dx.doi.org/10.1111/brv.12183</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/brv.12183" target="_blank" >10.1111/brv.12183</a>

Result language

angličtina

Original language name

From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology

Original language description

African annual fishes from the genus Nothobranchius are small teleosts that inhabit temporary water bodies subject to annual desiccation due to the alternation of the monsoon seasons. In the laboratory, adults of different Nothobranchius species and populations live between three and 18 months and, notably, there is a negative correlation between the captive lifespan of a species and the aridity of their habitat. Their short lifespan is coupled to rapid age-dependent functional decline and expression of cellular and molecular changes comparable to those observed in other vertebrates, including humans. The recent development of transgenesis in this species makes it possible to insert specific constructs into their genome, and the establishment of transgenic lines is facilitated by their very rapid generation time, which can be as short as one month. This makes Nothobranchius species particularly suited for investigating biological and molecular aspects of ageing and ageing-associated dysfunctions. At the same time, they also represent a unique model taxon to investigate the evolution of life-history adaptations and their genetic architecture. We review their natural history, including phylogenetic relationships, distribution in relation to habitat conditions and natural selection for differential longevity, population structure and demography, and life cycle with emphasis on diapause that may occur at three stages during embryonic development.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EG - Zoology

OECD FORD branch

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Project

<a href="/en/project/GAP506%2F11%2F0112" target="_blank" >GAP506/11/0112: The evolution and life-history consequences of rapid ageing</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biological Reviews

ISSN

1464-7931

e-ISSN

—

Volume of the periodical

91

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

23

Pages from-to

511-533

UT code for WoS article

000373906400014

EID of the result in the Scopus database

2-s2.0-84928753640