The effects of ciprofloxacin on early life stages of common carp (Cyprinus carpio)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F16%3A00453699" target="_blank" >RIV/68081766:_____/16:00453699 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/16:43874360 RIV/62157124:16270/16:43874360

Result on the web

<a href="http://dx.doi.org/10.1002/etc.3317" target="_blank" >http://dx.doi.org/10.1002/etc.3317</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/etc.3317" target="_blank" >10.1002/etc.3317</a>

Result language

angličtina

Original language name

The effects of ciprofloxacin on early life stages of common carp (Cyprinus carpio)

Original language description

We performed our toxicity test with ciprofloxacin (CIP) according to OECD 210, in which we used fertilized eggs of common carp. The tested concentrations were 1, 100, 500, 1000, and 3000 µg L1. We found accelerated hatching in all groups exposed to CIP, but significant growth reduction only in the group exposed to the highest concentration of CIP (3000 µg L1). An increased number of macroscopic morphological anomalies were observed on day 6 of the test (after hatching). The highest numbers of macroscopic morphological anomalies were observed in the groups of free embryos and larvae exposed to CIP concentrations of 100, 500, 1000 and 3000 µg L1 (20  23% of tested samples). A gradual decrease of glutathione S-transferase activity was detected in all experimental groups exposed to CIP, but significant differences (p < 0.01) were found only in groups treated with 500 and 3000 µg L1. Glutathione peroxidase and catalase exhibited increased activity in majority of the tested concentrations (p < 0.01, p < 0.05), while decreased glutathione reductase activity was found in the groups exposed to CIP concentrations of 500 and 3000 µg L1 (p < 0.05). The concentration of thiobarbituric acid reactive substances was significantly lower (p < 0.01) in all experimental groups exposed to CIP. The lowest observed effect concentration (LOEC) of CIP was 1 µg L1. These results suggest that hatching, early ontogeny, occurrence of morphological anomalies, activity of antioxidant and biotransformation enzymes and lipid peroxidation in fish can be affected by CIP.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EG - Zoology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Toxicology and Chemistry

ISSN

0730-7268

e-ISSN

—

Volume of the periodical

35

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

1733-1740

UT code for WoS article

000379547900015

EID of the result in the Scopus database

2-s2.0-84976588017