100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F17%3A00475331" target="_blank" >RIV/68081766:_____/17:00475331 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/s12864-017-3839-7" target="_blank" >http://dx.doi.org/10.1186/s12864-017-3839-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12864-017-3839-7" target="_blank" >10.1186/s12864-017-3839-7</a>

Result language
angličtina
Original language name
100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB
Original language description
Background: Gene duplication has led to a most remarkable adaptation involved in vertebrates’ host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds.nResults: Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds >100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history.nConclusions: Our results suggest that eroded footprints of gene duplication histories may mimic birth-death evolution and that in the avian MHC the presence of the two lineages may have been masked by elevated rates of concerted evolution in several taxa. Through the presence of a range of intermediate evolutionary stages along the homogenizing process of concerted evolution, the avian MHCIIB provides a remarkable illustration of the erosion of multigene family duplication history.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)

Project
<a href="/en/project/GAP505%2F10%2F1871" target="_blank" >GAP505/10/1871: Toll-like receptors in passerine birds: description, characterization of polymorphism and evolutionary consequences of allelic variation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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