Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F17%3A00477292" target="_blank" >RIV/68081766:_____/17:00477292 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.7554/eLife.27014" target="_blank" >http://dx.doi.org/10.7554/eLife.27014</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/eLife.27014" target="_blank" >10.7554/eLife.27014</a>

Result language

angličtina

Original language name

Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

Original language description

Gut bacteria occupy the interface between the organism and the external environment, contributing to homeostasis and disease. Yet, the causal role of the gut microbiota during host aging is largely unexplored. Here, using the African turquoise killifish (Nothobranchius furzeri), a naturally short-lived vertebrate, we show that the gut microbiota plays a key role in modulating vertebrate life span. Recolonizing the gut of middle-age individuals with bacteria from young donors resulted in life span extension and delayed behavioral decline. This intervention prevented the decrease in microbial diversity associated with host aging and maintained a younglike gut bacterial community, characterized by overrepresentation of the key genera Exiguobacterium, Planococcus, Propionigenium and Psychrobacter. Our findings demonstrate that the natural microbial gut community of young individuals can causally induce long-lasting beneficial systemic effects that lead to life span extension in a vertebrate model.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Project

<a href="/en/project/GA16-00291S" target="_blank" >GA16-00291S: Ageing in the wild: from demography to gene expression</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

eLife

ISSN

2050-084X

e-ISSN

—

Volume of the periodical

6

Issue of the periodical within the volume

e27014

Country of publishing house

GB - UNITED KINGDOM

Number of pages

26

Pages from-to

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UT code for WoS article

000408090300001

EID of the result in the Scopus database

2-s2.0-85030707641