Transcriptional host-pathogen responses of Pseudogymnoascus destructans and three species of bats with white-nose syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F20%3A00525379" target="_blank" >RIV/68081766:_____/20:00525379 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16270/20:43878810
Result on the web
<a href="https://doi.org/10.1080/21505594.2020.1768018" target="_blank" >https://doi.org/10.1080/21505594.2020.1768018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/21505594.2020.1768018" target="_blank" >10.1080/21505594.2020.1768018</a>
Alternative languages
Result language
angličtina
Original language name
Transcriptional host-pathogen responses of Pseudogymnoascus destructans and three species of bats with white-nose syndrome
Original language description
Understanding how context (e.g., host species, environmental conditions) drives disease susceptibility is an essential goal of disease ecology. We hypothesized that in bat white-nose syndrome (WNS), species-specific host-pathogen interactions may partly explain varying disease outcomes among host species. We characterized bat and pathogen transcriptomes in paired samples of lesion-positive and lesion-negative wing tissue from bats infected with Pseudogymnoascus destructans in three parallel experiments. The first two experiments analyzed samples collected from the susceptible Nearctic Myotis lucifugus and the less-susceptible Nearctic Eptesicus fuscus, following experimental infection and hibernation in captivity under controlled conditions. The third experiment applied the same analyses to paired samples from infected, free-ranging Myotis myotis, a less susceptible, Palearctic species, following natural infection and hibernation (n = 8 sample pairs/species). Gene expression by P. destructans was similar among the three host species despite varying environmental conditions among the three experiments and was similar within each host species between saprophytic contexts (superficial growth on wings) and pathogenic contexts (growth in lesions on the same wings). In contrast, we observed qualitative variation in host response: M. lucifugus and M. myotis exhibited systemic responses to infection, while E. fuscus up-regulated a remarkably localized response. Our results suggest potential phylogenetic determinants of response to WNS and can inform further studies of context-dependent host-pathogen interactions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
<a href="/en/project/GA17-20286S" target="_blank" >GA17-20286S: Physiology of bat hibernation with respect to multistressor impacts</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Virulence
ISSN
2150-5594
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
781-794
UT code for WoS article
000576193300002
EID of the result in the Scopus database
2-s2.0-85086691894