Coupling between tolerance and resistance for two related Eimeria parasite species
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F20%3A00535457" target="_blank" >RIV/68081766:_____/20:00535457 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/ece3.6986" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ece3.6986</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ece3.6986" target="_blank" >10.1002/ece3.6986</a>
Alternative languages
Result language
angličtina
Original language name
Coupling between tolerance and resistance for two related Eimeria parasite species
Original language description
Resistance (host capacity to reduce parasite burden) and tolerance (host capacity to reduce impact on its health for a given parasite burden) manifest two different lines of defense. Tolerance can be independent from resistance, traded off against it, or the two can be positively correlated because of redundancy in underlying (immune) processes. We here tested whether this coupling between tolerance and resistance could differ upon infection with closely related parasite species. We tested this in experimental infections with two parasite species of the genus Eimeria. We measured proxies for resistance (the (inverse of) number of parasite transmission stages (oocysts) per gram of feces at the day of maximal shedding) and tolerance (the slope of maximum relative weight loss compared to day of infection on number of oocysts per gram of feces at the day of maximal shedding for each host strain) in four inbred mouse strains and four groups of F1 hybrids belonging to two mouse subspecies, Mus musculus domesticus and Mus musculus musculus. We found a negative correlation between resistance and tolerance against Eimeria falciformis, while the two are uncoupled against Eimeria ferrisi. We conclude that resistance and tolerance against the first parasite species might be traded off, but evolve more independently in different mouse genotypes against the latter. We argue that evolution of the host immune defenses can be studied largely irrespective of parasite isolates if resistance-tolerance coupling is absent or weak (E. ferrisi) but host-parasite coevolution is more likely observable and best studied in a system with negatively correlated tolerance and resistance (E. falciformis).
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10618 - Ecology
Result continuities
Project
<a href="/en/project/GA16-23773S" target="_blank" >GA16-23773S: Phylogeography, selection and mutation rate at the whole-genome level: Inference from mtDNA sequences of the house mouse</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Ecology and Evolution
ISSN
2045-7758
e-ISSN
—
Volume of the periodical
10
Issue of the periodical within the volume
24
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
13938-13948
UT code for WoS article
000588357600001
EID of the result in the Scopus database
2-s2.0-85096699060