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Coupling between tolerance and resistance for two related Eimeria parasite species

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F20%3A00535457" target="_blank" >RIV/68081766:_____/20:00535457 - isvavai.cz</a>

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/10.1002/ece3.6986" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ece3.6986</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/ece3.6986" target="_blank" >10.1002/ece3.6986</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Coupling between tolerance and resistance for two related Eimeria parasite species

  • Original language description

    Resistance (host capacity to reduce parasite burden) and tolerance (host capacity to reduce impact on its health for a given parasite burden) manifest two different lines of defense. Tolerance can be independent from resistance, traded off against it, or the two can be positively correlated because of redundancy in underlying (immune) processes. We here tested whether this coupling between tolerance and resistance could differ upon infection with closely related parasite species. We tested this in experimental infections with two parasite species of the genus Eimeria. We measured proxies for resistance (the (inverse of) number of parasite transmission stages (oocysts) per gram of feces at the day of maximal shedding) and tolerance (the slope of maximum relative weight loss compared to day of infection on number of oocysts per gram of feces at the day of maximal shedding for each host strain) in four inbred mouse strains and four groups of F1 hybrids belonging to two mouse subspecies, Mus musculus domesticus and Mus musculus musculus. We found a negative correlation between resistance and tolerance against Eimeria falciformis, while the two are uncoupled against Eimeria ferrisi. We conclude that resistance and tolerance against the first parasite species might be traded off, but evolve more independently in different mouse genotypes against the latter. We argue that evolution of the host immune defenses can be studied largely irrespective of parasite isolates if resistance-tolerance coupling is absent or weak (E. ferrisi) but host-parasite coevolution is more likely observable and best studied in a system with negatively correlated tolerance and resistance (E. falciformis).

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10618 - Ecology

Result continuities

  • Project

    <a href="/en/project/GA16-23773S" target="_blank" >GA16-23773S: Phylogeography, selection and mutation rate at the whole-genome level: Inference from mtDNA sequences of the house mouse</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Ecology and Evolution

  • ISSN

    2045-7758

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    24

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    13938-13948

  • UT code for WoS article

    000588357600001

  • EID of the result in the Scopus database

    2-s2.0-85096699060