RNAseq analysis of brain aging in wild specimens of short-lived turquoise killifish: commonalities and differences with aging under laboratory conditions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F22%3A00564275" target="_blank" >RIV/68081766:_____/22:00564275 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/22:00128169
Result on the web
<a href="https://academic.oup.com/mbe/article-pdf/39/11/msac219/46875255/msac219.pdf" target="_blank" >https://academic.oup.com/mbe/article-pdf/39/11/msac219/46875255/msac219.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/molbev/msac219" target="_blank" >10.1093/molbev/msac219</a>
Alternative languages
Result language
angličtina
Original language name
RNAseq analysis of brain aging in wild specimens of short-lived turquoise killifish: commonalities and differences with aging under laboratory conditions
Original language description
A vast body of studies is available that describe age-dependent gene expression in relation to aging in a number of different model species. These data were obtained from animals kept in conditions with reduced environmental challenges, abundant food, and deprivation of natural sensory stimulation. Here, we compared wild- and captive aging in the short-lived turquoise killifish (Nothobranchius furzeri). These fish inhabit temporary ponds in the African savannah. When the ponds are flooded, eggs hatch synchronously, enabling a precise timing of their individual and population age. We collected the brains of wild fish of different ages and quantified the global age-dependent regulation of transcripts using RNAseq. A major difference between captive and wild populations is that wild populations had unlimited access to food and hence grew to larger sizes and reached asymptotic size more rapidly, enabling the analysis of age-dependent gene expression without the confounding effect of adult brain growth. We found that the majority of differentially expressed genes show the same direction of regulation in wild and captive populations. However, a number of genes were regulated in opposite direction. Genes downregulated in the wild and upregulated in captivity were enriched for terms related to neuronal communication. Genes upregulated in the wild and downregulated in captive conditions were enriched in terms related to DNA replication. Finally, the rate of age-dependent gene regulation was higher in wild animals, suggesting a phenomenon of accelerated aging.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10613 - Zoology
Result continuities
Project
<a href="/en/project/GA19-01781S" target="_blank" >GA19-01781S: The sources of intra-population heterogeneity in senescence</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Biology and Evolution
ISSN
0737-4038
e-ISSN
1537-1719
Volume of the periodical
39
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
msac219
UT code for WoS article
000879850000007
EID of the result in the Scopus database
2-s2.0-85141892367