Hibecovirus (genus Betacoronavirus) infection linked to gut microbial dysbiosis in bats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F25%3A00618930" target="_blank" >RIV/68081766:_____/25:00618930 - isvavai.cz</a>

Result on the web

<a href="https://academic.oup.com/ismecommun/article/5/1/ycae154/7925803" target="_blank" >https://academic.oup.com/ismecommun/article/5/1/ycae154/7925803</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ismeco/ycae154" target="_blank" >10.1093/ismeco/ycae154</a>

Result language

angličtina

Original language name

Hibecovirus (genus Betacoronavirus) infection linked to gut microbial dysbiosis in bats

Original language description

Little is known about how zoonotic virus infections manifest in wildlife reservoirs. However, a common health consequence of enteric virus infections is gastrointestinal diseases following a shift in gut microbial composition. The sub-Saharan hipposiderid bat complex has recently emerged to host at least three coronaviruses (CoVs), with Hipposideros caffer D appearing particularly susceptible to Hibecovirus CoV-2B infection. In this study, we complement body condition and infection status data with information about the gut microbial community to understand the health impact of CoV infections in a wild bat population. Of the three CoVs, only infections with the distantly SARS-related Hibecovirus CoV-2B were associated with lower body condition and altered the gut microbial diversity and composition. The gut microbial community of infected bats became progressively less diverse and more dissimilar with infection intensity, arguing for dysbiosis as per the Anna Karenina principle. Putatively beneficial bacteria, such as Alistipes and Christensenella, decreased with infection intensity, while potentially pathogenic bacteria, namely Mycoplasma and Staphylococcus, increased. Infections with enterically replicating viruses may therefore cause changes in body condition and gut dysbiosis with potential negative health consequences even in virus reservoirs. We argue that high-resolution data on multiple health markers, ideally including microbiome information, will provide a more nuanced picture of bat disease ecology.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10607 - Virology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ISME Communications

ISSN

2730-6151

e-ISSN

2730-6151

Volume of the periodical

5

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

ycae154

UT code for WoS article

001457011300001

EID of the result in the Scopus database

2-s2.0-105004922512