The neuro-immune crosstalk between periphery and central nervous system during acute immune response to virus-mimicking RNA in parrots

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F25%3A00640277" target="_blank" >RIV/68081766:_____/25:00640277 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/25:10504324

Result on the web

<a href="https://royalsocietypublishing.org/doi/10.1098/rsos.251343" target="_blank" >https://royalsocietypublishing.org/doi/10.1098/rsos.251343</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1098/rsos.251343" target="_blank" >10.1098/rsos.251343</a>

Result language

angličtina

Original language name

The neuro-immune crosstalk between periphery and central nervous system during acute immune response to virus-mimicking RNA in parrots

Original language description

Parrots, valued companion animals with a concerning conservation status, can act as reservoirs for zoonotic diseases. During various infections, systemic inflammation significantly impairs host health. However, the regulation of inflammatory responses in birds, particularly in cognitively advanced parrots, remains poorly understood. Here, we examine parrot systemic inflammation in response to virus-mimicking stimulation. In budgerigars (Melopsittacus undulatus), a novel model for neuroinflammation research, we induced sterile inflammation with synthetic poly(I:C) RNA and analysed dose-, time- and tissue-dependent gene expression patterns of key markers, including TLR3, NLRP3, CASP1, IL1B and IL6, during acute immune response. We report a significant relationship between cytokine expression (IL1B, IL6) in the intestine (local response) and brain (systemic response) that has not yet been described after viral stimulation in parrots. Peripheral IL6 expression was upregulated at 3-6 h after stimulation with poly(I:C). In the brain, multiple genes (TLR3, IL1B and IL6) showed activation early during the immune response. These findings highlight the susceptibility of parrots to neuroinflammation following viral infections, having specific relevance for basic research in neurobiology, immunology and behavioural science, and also veterinary research in psittacine birds. Our study provides a foundation for future comparative research on avian neuro-immune crosstalk and neuroinflammation-related behavioural disorders.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10613 - Zoology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Royal Society Open Science

ISSN

2054-5703

e-ISSN

2054-5703

Volume of the periodical

12

Issue of the periodical within the volume

10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

251343

UT code for WoS article

001589336500001

EID of the result in the Scopus database

2-s2.0-105018074672