Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F03%3A19033062" target="_blank" >RIV/68378041:_____/03:19033062 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2.
Original language description
In this study lipoxygenase inhibitors were used to study the role of arachidonic acid metabolism in regulation of proliferation and apoptosis of chicken monoblasts BM2 and its functional interaction with Jun proteins. It was demonstrated that lipoxygenase inhibitors further enforce tumor suppresive capabilities of Jun proteins by inducing either more efficient cell cycle block and/or apoptosis in BM2 cells. This suggests that there is a crosstalk between the lipoxygenase- and Jun-directed pathways in regulation of proliferation and differentiation of leukemic cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Prastaglandis & other lipid mediators
ISSN
1098-8823
e-ISSN
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Volume of the periodical
72
Issue of the periodical within the volume
N/A
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
131-145
UT code for WoS article
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EID of the result in the Scopus database
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