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Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F03%3A19033062" target="_blank" >RIV/68378041:_____/03:19033062 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2.

  • Original language description

    In this study lipoxygenase inhibitors were used to study the role of arachidonic acid metabolism in regulation of proliferation and apoptosis of chicken monoblasts BM2 and its functional interaction with Jun proteins. It was demonstrated that lipoxygenase inhibitors further enforce tumor suppresive capabilities of Jun proteins by inducing either more efficient cell cycle block and/or apoptosis in BM2 cells. This suggests that there is a crosstalk between the lipoxygenase- and Jun-directed pathways in regulation of proliferation and differentiation of leukemic cells.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2003

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Prastaglandis & other lipid mediators

  • ISSN

    1098-8823

  • e-ISSN

  • Volume of the periodical

    72

  • Issue of the periodical within the volume

    N/A

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    15

  • Pages from-to

    131-145

  • UT code for WoS article

  • EID of the result in the Scopus database