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Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F05%3A00026094" target="_blank" >RIV/68378041:_____/05:00026094 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/05:00021444

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells

  • Original language description

    Although the detection of several components of the fibroblast growth factor (FGF) signaling pathway in human embryonic stem cells (hESCs) has been reported, the functionality of that pathway and effects on cell fate decisions are yet to be established.In this study the expression of FGF-2, the prototypic member of the FGF family, and its receptors (FGFRs) was analyzed in undifferentiated and differentiating hESCs. The effects of FGF-2 on hESCs, acting as both exogenous and endogenous factor was also assessed. Based on the obtained data, we propose that endogenous FGF signaling pathway can be implicated in self-renewal and/or differentiation of hESCs.

  • Czech name

    Exprese a potenciální úloha fibroblastového faktoru 2 a jeho receptorů u lidských embryonálních kmenových buněk

  • Czech description

    Ačkoliv u lidských embryonálních kmenových (ES) buněk již byly popsány různé komponenty signální dráhy fibroblastového růstového faktoru (FGF), funkčnost této signální dráhy nebyla dosud dobře prostudována. V této studii byla analyzována exprese FGF-2 ajeho receptorů (FGFR) v nediferencovaných a diferencujících lidských ES buňkách. Také byly analyzovány biologické efekty FGF. Data ukazují, že zejména signálování endogenním FGF se může uplatňovat v řízení sebeobnovy a diferenciace lidských ES buněk.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Stem Cells

  • ISSN

    1066-5099

  • e-ISSN

  • Volume of the periodical

    23

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    12

  • Pages from-to

    1200-1211

  • UT code for WoS article

  • EID of the result in the Scopus database