Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition during Hippocampal Maturation In Vitro
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F05%3A00026240" target="_blank" >RIV/68378041:_____/05:00026240 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition during Hippocampal Maturation In Vitro
Original language description
Reelin is a secreted protein that regulates brain layer formation during embryonic development. Reelin binds several receptors, including two members of the low-density lipoprotein (LDL) receptor family, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR). Despite the high level of expression of Reelin and ApoER2 in the postnatal brain, their functions in the adult CNS remain elusive. Here, using electrophysiological, immunocytochemical, and biochemical approaches in cultured postnatal hippocampal neurons, we show that Reelin controls the change in subunit composition of somatic NMDA glutamate receptors (NMDARs) during maturation.
Czech name
Reelin, velmi-nízce-densní Lipoproteinový receptor, a Receptor 2 pro Apolipoprotein kontroluje komposici somatického NMDA receptoru během dozrávání hippocampu In Vitro
Czech description
V této publikaci dokládáme na buněčných primárních kulturách, velmi-nízce-densní Lipoproteinový receptor Reelin a Receptor 2 pro Apolipoprotein kontroluje podjednotkové složení N-methyl D-aspartátového receptoru (NMDA receptor) na buněčných tělech běhemmaturace.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuroscience
ISSN
0270-6474
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
26
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
6127-6136
UT code for WoS article
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EID of the result in the Scopus database
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