Nucleotide analogues with immunobiological properties: 9-[2-hydroxy-3-(phosphonomethoxy)propyl]adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F06%3A00043783" target="_blank" >RIV/68378041:_____/06:00043783 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Nucleotide analogues with immunobiological properties: 9-[2-hydroxy-3-(phosphonomethoxy)propyl]adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives
Original language description
Acyclic nucleoside phosphonate 9-[2-hydroxy-3-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) augments production of nitric oxide by macrophages and stimulates secretion of cytokines and chemokines implied in replication and/or penetration of HIV in cells. The N6-derivatives were biologically less active or inactive.
Czech name
Analogy nukleotidů s imunobiologickými vlastnostmi: 9-[2-hydroxy-3-(fosfonometoxy)propyl]adenin (HPMPA), -2,6-diaminopurin (HPMPDAP), a jejich N6-substituované deriváty
Czech description
Acyklický nukleosidfosfonáf 9-[2-hydroxy-3-(fosfonometoxy)propyl]-2,6-diaminopurin (HPMPDAP) zvyšuje u makrofágů produkci oxidu dusnatého a stimuluje sekreci cytokinů, které interferují s replikací nebo průnikem viru HIV do buněk. Deriváty substituovanév pozici N6 byly biologicky méně aktivní nebo neaktivní.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Result description