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Histone deacetylase inhibitors suppress IFN(alpha)-induced up-regulation of promyelocytic leukemia protein

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F07%3A00083219" target="_blank" >RIV/68378041:_____/07:00083219 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Histone deacetylase inhibitors suppress IFN(alpha)-induced up-regulation of promyelocytic leukemia protein

  • Original language description

    We have descibed for the first time that histone deacetylases (HDAC) inhibitors (trichostatin A, sodium butyrate, MS-275, SAHA, and valproic acid) supress interferon alpha (IFN alpha)-induced up regulation of promyelocytic leukemia protein (PML) at mRNAand protein levels in several human cell lines and in normal diploid skin fibroblasts. Additionaly, HDAC inhibitors blocked an increase of PML nuclear bodies number in response to IFN (alpha)-stimulation. We showed that the effect of HDAC inhibitors on IFN (alpha)-pathway is STAT2- independent.

  • Czech name

    Inhibitory histondeacetyláz suprimují IFN(alfa)-indukovanou up-regulaci promyelocytarního leukemia proteinu

  • Czech description

    Jako první jsme popsali, že inhibitory histondeacetyláz (trichostatin A, butyrát sodný, MS-275, SAHA a kyselina valproová) suprimují interferonem alfa (IFN alfa) zprostředkovanou indukci promyelocytárního leukemia proteinu (PML) na úrovni mRNA a proteinuv několika lidských buněčných liniích a v normálních diploidních kožních fibroblastech. Dále inhibitory histondeacetyláz blokovaly nárust počtu PML jaderných tělísek po stimulaci IFN alfa. Prokázali jsme, že efekt histondeacetylázových inhibitorů na IFNalfa dráhu je nezavislý na STAT2.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Blood

  • ISSN

    0006-4971

  • e-ISSN

  • Volume of the periodical

    109

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    1373-1380

  • UT code for WoS article

  • EID of the result in the Scopus database