Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F10%3A00347601" target="_blank" >RIV/68378041:_____/10:00347601 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits
Original language description
GABA(B) receptors are the G-protein-coupled receptors for GABA, the main inhibitory neurotransmitter in the brain. We show by functional proteomics that GABA(B) receptors in the brain are high-molecular-mass complexes of GABA(B1), GABA(B2) and members ofa subfamily of the KCTD proteins. KCTD proteins associate tightly with the carboxy terminus of GABA(B2) as auxiliary subunits of GABA(B) receptors and determine the pharmacology and kinetics of the receptor response.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA309%2F06%2F1304" target="_blank" >GA309/06/1304: The role of GABA-B receptors in the mammalian MNTB</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature
ISSN
0028-0836
e-ISSN
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Volume of the periodical
465
Issue of the periodical within the volume
7295
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
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UT code for WoS article
000277558500038
EID of the result in the Scopus database
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