Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F10%3A00347653" target="_blank" >RIV/68378041:_____/10:00347653 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors

Original language description

The study tested the hypothesis that associations of PAH-related exposures with breast cancer differ according to tumor p53 mutation status, effect, type, and number. This possibility was examined in a population-based case-control study where p53 mutations in 859 tumors were detected. Participants with p53 mutations were less likely to be exposed to polycyclic aromatic hydrocarbons (PAHs) than participants without mutations. In conclusion, the study suggests that PAHs may be associated with specific breast tumor p53 mutation subgroup rather than with overall p53 mutations and may be related to breast cancer through mechanisms other than p53 mutation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Health Perspectives

ISSN

0091-6765

e-ISSN

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Volume of the periodical

118

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

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UT code for WoS article

000276454800024

EID of the result in the Scopus database

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