Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F11%3A00353964" target="_blank" >RIV/68378041:_____/11:00353964 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure

Original language description

This mini-review presents the current stage of development of the Metasystems Metafer MNScore system for automated image analysis scoring of micronuclei (MN) in human lymphocytes. A new field for application of this method was opened in 2009, when it wasused in a biomonitoring study, assessing the effect of exposure to carcinogenic PAHs in ambient air on the frequency of MN in a group of policemen from Prague. The data from further studies are also presented, in which the above mentioned analysis system was used to evaluate the impact of air pollution on MN in bus drivers, asthmatic children, office and laboratory workers. It is concluded that the automated image analysis is a promising tool for improving risk assessment of human populations exposed to environmental or occupational mutagens.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mutagenesis

ISSN

0267-8357

e-ISSN

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Volume of the periodical

26

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

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UT code for WoS article

000285627700025

EID of the result in the Scopus database

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