Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F11%3A00368688" target="_blank" >RIV/68378041:_____/11:00368688 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/cddis.2011.79" target="_blank" >http://dx.doi.org/10.1038/cddis.2011.79</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/cddis.2011.79" target="_blank" >10.1038/cddis.2011.79</a>

Result language
angličtina
Original language name
Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study
Original language description
Here, we analysed the ultrastructural localisation, distribution and numerical density of hippocampal SERT axons (SERT-Ax) and terminals (SERT-Te) and their relationship with SERT fibre sprouting and altered synaptic density in 3xTg-AD compared with non-transgenic control mice. Our results suggested that concomitant increase in density of serotonergic terminals and reduction in the number of perforated axospinous synapses in 3xTg-AD mice (a model of Alzheimer?s disease) may act as a compensatory mechanism maintaining synaptic efficacy as a response to the AD cognitive impairment.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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