Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F11%3A00375584" target="_blank" >RIV/68378041:_____/11:00375584 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1042/AN20110025" target="_blank" >http://dx.doi.org/10.1042/AN20110025</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1042/AN20110025" target="_blank" >10.1042/AN20110025</a>

Result language
angličtina
Original language name
Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease.
Original language description
Our results suggest that cognitive deterioration during the progression of the Alzheimer disease can be associated with an early reduction of astrocytic arborization and shrinkage of the astroglial domain, which may affect synaptic connectivity within the EC and between the EC and other brain regions. Additionally, the EC seems to be particularly vulnerable to AD pathology because of the absence of evident astrogliosis in response to Ab accumulation.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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