COGENT (COlorectal cancer GENeTics) revisited

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F12%3A00383027" target="_blank" >RIV/68378041:_____/12:00383027 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/mutage/ger059" target="_blank" >http://dx.doi.org/10.1093/mutage/ger059</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/mutage/ger059" target="_blank" >10.1093/mutage/ger059</a>

Result language
angličtina
Original language name
COGENT (COlorectal cancer GENeTics) revisited
Original language description
Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This hasbeen the motivation for establishing the COGENT(COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying lowpenetrance variants for CRC and the current and future challenges for COGENT.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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