High tryptophan diet reduces CA1 intraneuronal ss-amyloid in the triple transgenic mouse model of Alzheimer's disease.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F12%3A00384005" target="_blank" >RIV/68378041:_____/12:00384005 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1474-9726.2012.00845.x" target="_blank" >http://dx.doi.org/10.1111/j.1474-9726.2012.00845.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1474-9726.2012.00845.x" target="_blank" >10.1111/j.1474-9726.2012.00845.x</a>
Alternative languages
Result language
angličtina
Original language name
High tryptophan diet reduces CA1 intraneuronal ss-amyloid in the triple transgenic mouse model of Alzheimer's disease.
Original language description
Alzheimer's disease (AD) is a progressive neurodegenerative disease that impairs mnesic functions. The histopathology of the disease is manifested by the accumulation of intracellular ?-amyloid (A?) and subsequent formation of neuritic plaques as well asthe presence neurofibrillary tangles in specific brain regions associated with learning and memory including the hippocampus. Our results show that increased dietary TrP intake reduces intraneuronal A? load in the 3xTg-AD mouse model of AD, suggesting that enhanced TrP intake and in consequence a potential increase in 5-HT neurotransmission may be effective in reducing plaque pathology in AD.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Aging Cell
ISSN
1474-9718
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
810-822
UT code for WoS article
000308871400010
EID of the result in the Scopus database
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