Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F14%3A00395393" target="_blank" >RIV/68378041:_____/14:00395393 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/ijc.28383" target="_blank" >http://dx.doi.org/10.1002/ijc.28383</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ijc.28383" target="_blank" >10.1002/ijc.28383</a>

Result language
angličtina
Original language name
Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk
Original language description
Polymorphisms in MMR (mismatch repair) or other DNA repair gene variants may modify the association between recreational physical activity (RPA) and breast cancer incidence. In this study, the individual and joint effects of variants in three MMR pathwaygenes (MSH3, MLH1 and MSH2) on breast cancer occurence using resources from the Long Island Breast Cancer Study Project were investigated. Additionally, the interactions between RPA and genetic polymorphisms in MMR, BER (base excision repair) and NER (nucleotide excision repair) pathways were characterized. Obtained data show that women with minor alleles in both MSH2 and MLH1 could be at increased breast cancer risk. RPA may be modified by genes in the DNA repair pathway, and merit further investigation.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
—

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)