DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/?-catenin signaling pathway genes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F14%3A00428629" target="_blank" >RIV/68378041:_____/14:00428629 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2217/EPI.14.7" target="_blank" >http://dx.doi.org/10.2217/EPI.14.7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/EPI.14.7" target="_blank" >10.2217/EPI.14.7</a>

Result language
angličtina
Original language name
DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/?-catenin signaling pathway genes
Original language description
The aim of the present study was to address the DNA methylation status of genes relevant in colorectal carcinogenesis and its progression, such as genes frequently mutated in CRC, genes involved in the DNA repair and Wnt signaling pathway. Aberrant methylation of the DCLRE1C and GPC6 genes are presented here for the first time and are therefore of special interest for further validation as novel candidate biomarker genes in CRC, and merit further validation with specific assays.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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