Altered Astrocytic Swelling in the Cortex of ?-Syntrophin-Negative GFAP/EGFP Mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F14%3A00436669" target="_blank" >RIV/68378041:_____/14:00436669 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/14:00436669
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0113444" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0113444</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0113444" target="_blank" >10.1371/journal.pone.0113444</a>

Result language
angličtina
Original language name
Altered Astrocytic Swelling in the Cortex of ?-Syntrophin-Negative GFAP/EGFP Mice
Original language description
In the present study we quantified cell volume changes in astrocytes lacking ?-syntrophin thanks to the successful generation of GFAP/EGFP/?-Syn-/- mice, which enabled us to visualize astrocytes based on EGFP expression. We demonstrated that ?-syntrophinknockout results in smaller astrocytic swelling when induced by severe hypoosmotic stress, OGD or high extracellular K+, and it also affects astrocyte volume changes during the washout period following mild hypo- and hyperosmotic stress, and 10 mMK+.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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