Excess NF-kB induces ectopic odontogenesis in embryonic incisor epithelium
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F15%3A00438519" target="_blank" >RIV/68378041:_____/15:00438519 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1177/0022034514556707" target="_blank" >http://dx.doi.org/10.1177/0022034514556707</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/0022034514556707" target="_blank" >10.1177/0022034514556707</a>
Alternative languages
Result language
angličtina
Original language name
Excess NF-kB induces ectopic odontogenesis in embryonic incisor epithelium
Original language description
Nuclear factor kappa B (NF-?B) signaling plays critical roles in many physiological and pathological processes, including regulating organogenesis. Down-regulation of NF-?B signaling during development results in hypohidrotic ectodermal dysplasia. The roles of NF-?B signaling in tooth development, however, are not fully understood. We examined mice overexpressing IKK?, an essential component of the NF-?B pathway, under keratin 5 promoter (K5-Ikk?). K5-Ikk? mice showed supernumerary incisors whose formation was accompanied by up-regulation of canonical Wnt signaling. Apoptosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikk? mice. The supernumerary incisors in K5-Ikk? mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise. Excess NF-?B activity thus induces an ectopic odontogenesis program that is usually suppressed under physiological conditions.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GB14-37368G" target="_blank" >GB14-37368G: Centre of orofacial development and regeneration</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Dental Research
ISSN
0022-0345
e-ISSN
—
Volume of the periodical
94
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
121-128
UT code for WoS article
000346506200016
EID of the result in the Scopus database
2-s2.0-84919464755