Differentiation potential of neonatal neural stem/progenitor cells is affected by WNT signaling

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F15%3A00455570" target="_blank" >RIV/68378041:_____/15:00455570 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/15:00455570
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Differentiation potential of neonatal neural stem/progenitor cells is affected by WNT signaling
Original language description
The canonical Wnt signaling pathway plays an important role in embryogenesis and in establishment of neurogenic niches. Studies using embryonic and neonatal mice suggested involvement of Wnt/beta-catenin signaling in proliferation and differentiation ofneural progenitors. The effect of Wnt signaling on the differentiation potential of neonatal neural stem/progenitor cells (NS/PCs) and their membrane properties was studied eight days after the onset of in vitro differentiation. To manipulate Wnt signaling at different subcellular levels, three transgenic mouse strains were employed, which enabled either inhibition of the pathway at the nuclear or cell membrane level, or activation of Wnt signaling in the cytoplasm using the Cre-loxP system. To follow the fate of NS/PCs, the patch-clamp technique, immunocytochemistry, calcium imaging, Western blot, and quantitative RT-PCR (RT-qPCR) was utilized. Within differentiated cells we found three electrophysiologically and immunocytochemically d
Czech name
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Czech description
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Project
<a href="/en/project/GAP303%2F12%2F0855" target="_blank" >GAP303/12/0855: Polydendrocyte function in regeneration after ischemic brain injury - the role of Wnt signaling pathway</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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