Human multipotent mesenchymal stromal cells in the treatment of postoperative temporal bone defect: an animal model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00450151" target="_blank" >RIV/68378041:_____/16:00450151 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/16:10320100 RIV/00216208:11150/16:10320100 RIV/00179906:_____/16:10320100
Result on the web
<a href="http://dx.doi.org/10.3727/096368915X689730" target="_blank" >http://dx.doi.org/10.3727/096368915X689730</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3727/096368915X689730" target="_blank" >10.3727/096368915X689730</a>
Alternative languages
Result language
angličtina
Original language name
Human multipotent mesenchymal stromal cells in the treatment of postoperative temporal bone defect: an animal model
Original language description
Canal wall down mastoidectomy is one of the most effective treatments for cholesteatoma. However, it results in anatomical changes in the external and middle ear with a negative impact on the patient's quality of life. To provide complete closure of the mastoid cavity and normalize the anatomy of the middle and external ear, we used human multipotent mesenchymal stromal cells (hMSCs), GMP grade, in a guinea pig model. A method for preparing a biomaterial composed of hMSCs, hydroxyapatite, and tissue glue was developed. Animals from the treated group were implanted with biomaterial composed of hydroxyapatite and hMSCs, while animals in the control group received hydroxyapatite alone. When compared to controls, the group implanted with hMSCs showed a significantly higher ratio of new bone formation (p = 0.00174), as well as a significantly higher volume percentage of new immature bone (p = 0.00166). Our results proved a beneficial effect of hMSCs on temporal bone formation and provided a promising tool to improve the quality of life of patients after canal wall down mastoidectomy by hMSC implantation.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LO1309" target="_blank" >LO1309: Cell Therapy and Tissue Repair</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Transplantation
ISSN
0963-6897
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
28
Pages from-to
1405-1414
UT code for WoS article
000384801200017
EID of the result in the Scopus database
2-s2.0-84978134221