All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

The Supportive Role of Insulin-Like Growth Factor-I in the Differentiation of Murine Mesenchymal Stem Cells into Corneal-Like Cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00459568" target="_blank" >RIV/68378041:_____/16:00459568 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/16:10325534 RIV/00216208:11110/16:10325534

  • Result on the web

    <a href="http://dx.doi.org/10.1089/scd.2016.0030" target="_blank" >http://dx.doi.org/10.1089/scd.2016.0030</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1089/scd.2016.0030" target="_blank" >10.1089/scd.2016.0030</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The Supportive Role of Insulin-Like Growth Factor-I in the Differentiation of Murine Mesenchymal Stem Cells into Corneal-Like Cells

  • Original language description

    Mesenchymal stem cells (MSCs) possess potent immunoregulatory properties and are a source of numerous growth and trophic factors. These properties make them promising candidate for ocular surface regeneration. It was demonstrated that MSCs can express markers of corneal epithelial cells and keratocytes under selected conditions. In previous study, we found that insulin-like growth factor-I (IGF-I) supports the differentiation of limbal stem cells into corneal-like cells. In the present study, we tested differentiation of mouse bone marrow-derived MSCs into corneal epithelial cells using the extract from the cornea and IGF-I. The results show that MSCs cultured in the presence of corneal extract and IGF-I efficiently differentiate into corneal-like cells. The differentiated cells possess characteristics of corneal epithelial cells and keratocytes and at the same time maintain MSC properties.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Stem Cells and Development

  • ISSN

    1547-3287

  • e-ISSN

  • Volume of the periodical

    7

  • Issue of the periodical within the volume

    17

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    23156-23169

  • UT code for WoS article

    000377383700006

  • EID of the result in the Scopus database

    2-s2.0-84971501039