The Supportive Role of Insulin-Like Growth Factor-I in the Differentiation of Murine Mesenchymal Stem Cells into Corneal-Like Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00459568" target="_blank" >RIV/68378041:_____/16:00459568 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/16:10325534 RIV/00216208:11110/16:10325534
Result on the web
<a href="http://dx.doi.org/10.1089/scd.2016.0030" target="_blank" >http://dx.doi.org/10.1089/scd.2016.0030</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/scd.2016.0030" target="_blank" >10.1089/scd.2016.0030</a>
Alternative languages
Result language
angličtina
Original language name
The Supportive Role of Insulin-Like Growth Factor-I in the Differentiation of Murine Mesenchymal Stem Cells into Corneal-Like Cells
Original language description
Mesenchymal stem cells (MSCs) possess potent immunoregulatory properties and are a source of numerous growth and trophic factors. These properties make them promising candidate for ocular surface regeneration. It was demonstrated that MSCs can express markers of corneal epithelial cells and keratocytes under selected conditions. In previous study, we found that insulin-like growth factor-I (IGF-I) supports the differentiation of limbal stem cells into corneal-like cells. In the present study, we tested differentiation of mouse bone marrow-derived MSCs into corneal epithelial cells using the extract from the cornea and IGF-I. The results show that MSCs cultured in the presence of corneal extract and IGF-I efficiently differentiate into corneal-like cells. The differentiated cells possess characteristics of corneal epithelial cells and keratocytes and at the same time maintain MSC properties.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Stem Cells and Development
ISSN
1547-3287
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
17
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
23156-23169
UT code for WoS article
000377383700006
EID of the result in the Scopus database
2-s2.0-84971501039