Immediate manifestation of acoustic trauma in the auditory cortex is layer specific and cell type dependent

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00459640" target="_blank" >RIV/68378041:_____/16:00459640 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1152/jn.00810.2015" target="_blank" >http://dx.doi.org/10.1152/jn.00810.2015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1152/jn.00810.2015" target="_blank" >10.1152/jn.00810.2015</a>

Result language

angličtina

Original language name

Immediate manifestation of acoustic trauma in the auditory cortex is layer specific and cell type dependent

Original language description

Exposure to loud sounds damages the auditory periphery and induces maladaptive changes in central parts of the auditory system. Diminished peripheral afferentation and altered inhibition influence the processing of sounds in the auditory cortex. It is unclear, however, which types of inhibitory interneurons are affected by acoustic trauma. Here we used single-unit electrophysiological recording and two-photon calcium imaging in anesthetized mice to evaluate the effects of acute acoustic trauma (125 dB SPL, white noise, 5 min) on the response properties of neurons in the core auditory cortex. Electrophysiological measurements suggested the selective impact of acoustic trauma on inhibitory interneurons in the auditory cortex. To further investigate which interneuronal types were affected, we used two-photon calcium imaging to record the activity of neurons in cortical layers 2/3 and 4, specifically focusing on parvalbumin-positive (PV +) and somatostatin-positive (SST +) interneurons. Spontaneous and pure-tone-evoked firing rates of SST + interneurons increased in layer 4 immediately after acoustic trauma and remained almost unchanged in layer 2/3. Furthermore, PV + interneurons with high best frequencies increased their evoked-to-spontaneous firing rate ratios only in layer 2/3 and did not change in layer 4. Finally, acoustic trauma unmasked low-frequency excitatory inputs only in layer 2/3. Our results demonstrate layer-specific changes in the activity of auditory cortical inhibitory interneurons within minutes after acoustic trauma.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neurophysiology

ISSN

0022-3077

e-ISSN

—

Volume of the periodical

115

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

1860-1874

UT code for WoS article

000376056900001

EID of the result in the Scopus database

2-s2.0-84984597147