The Microbiota Determines Susceptibility to Experimental Autoimmune Uveoretinitis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00462003" target="_blank" >RIV/68378041:_____/16:00462003 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/16:00463355 RIV/00216208:11110/16:10326833 RIV/00064165:_____/16:10326833
Result on the web
<a href="http://dx.doi.org/10.1155/2016/5065703" target="_blank" >http://dx.doi.org/10.1155/2016/5065703</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2016/5065703" target="_blank" >10.1155/2016/5065703</a>

Result language
angličtina
Original language name
The Microbiota Determines Susceptibility to Experimental Autoimmune Uveoretinitis
Original language description
The microbiota is a crucial modulator of the immune system. Here, we evaluated how its absence or reduction modifies the inflammatory response in the murine model of experimental autoimmune uveoretinitis (EAU). We induced EAU in germ-free (GF) or conventionally housed (CV) mice and in CV mice treated with a combination of broad-spectrum antibiotics either from the day of EAU induction or from one week prior to induction of disease. The severity of the inflammation was assessed by fundus biomicroscopy or by histology, including immunohistology. The immunophenotyping of T cells in local and distant lymph nodes was performed by flow cytometry. We found that GF mice and mice where the microbiota was reduced one week before EAU induction were protected from severe autoimmune inflammation. GF mice had lower numbers of infiltrating macrophages and significantly less T cell infiltration in the retina than CV mice with EAU. GF mice also had reduced numbers of IFN-gamma and IL-17-producing T cells and increased numbers of regulatory T cells in the eye-draining lymph nodes. These data suggest that the presence of microbiota during autoantigen recognition regulates the inflammatory response by influencing the adaptive immune response.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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